The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| WASF1-20-RE | 20 (40 μL) | 200 μL |  |
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| WASF1-20-OR | 20 (40 μL) | 200 μL |  |
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| WASF1-20-GO | 20 (40 μL) | 200 μL |  |
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| WASF1-20-GR | 20 (40 μL) | 200 μL |  |
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| WASF1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : WASF1
Gene Name : WAS protein family member 1
Chromosome : CHR 6: 110,189,873-110,099,816
Locus : 6q21
Alt. Genes : RAD50
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