This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UHRF2-20-RE | 20 (40 μL) | 200 μL |  |
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| UHRF2-20-OR | 20 (40 μL) | 200 μL |  |
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| UHRF2-20-GO | 20 (40 μL) | 200 μL |  |
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| UHRF2-20-GR | 20 (40 μL) | 200 μL |  |
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| UHRF2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Gene Symbol : UHRF2
Gene Name : Ubiquitin like with PHD and ring finger domains 2
Chromosome : CHR 9: 641,314,7-650,810,7
Locus : 9p24.1
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