This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBE4A-20-RE | 20 (40 μL) | 200 μL |  |
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| UBE4A-20-OR | 20 (40 μL) | 200 μL |  |
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| UBE4A-20-GO | 20 (40 μL) | 200 μL |  |
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| UBE4A-20-GR | 20 (40 μL) | 200 μL |  |
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| UBE4A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Symbol : UBE4A
Gene Name : Ubiquitination factor E4A
Chromosome : CHR 11: 118,359,580-118,399,210
Locus : 11q23.3
Alt. Genes : KIF20A
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