This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOP3A-20-RE | 20 (40 μL) | 200 μL |  |
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| TOP3A-20-OR | 20 (40 μL) | 200 μL |  |
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| TOP3A-20-GO | 20 (40 μL) | 200 μL |  |
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| TOP3A-20-GR | 20 (40 μL) | 200 μL |  |
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| TOP3A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Symbol : TOP3A
Gene Name : DNA topoisomerase III alpha
Chromosome : CHR 17: 183,150,91-182,699,57
Locus : 17p11.2
Alt. Genes : FEM1B
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