This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNK2-20-RE | 20 (40 μL) | 200 μL |  |
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| TNK2-20-OR | 20 (40 μL) | 200 μL |  |
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| TNK2-20-GO | 20 (40 μL) | 200 μL |  |
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| TNK2-20-GR | 20 (40 μL) | 200 μL |  |
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| TNK2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : TNK2
Gene Name : Tyrosine kinase non receptor 2
Chromosome : CHR 3: 195,909,008-195,863,363
Locus : 3q29
Alt. Genes : ZNF263
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