The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF1B-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF1B-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF1B-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF1B-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF1B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Gene Symbol : TNFRSF1B
Gene Name : TNF receptor superfamily member 1B
Chromosome : CHR 1: 121,669,47-122,092,21
Locus : 1p36.22
Alt. Genes : PDZK1IP1
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