The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFAIP6-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFAIP6-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFAIP6-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFAIP6-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFAIP6-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
Gene Symbol : TNFAIP6
Gene Name : TNF alpha induced protein 6
Chromosome : CHR 2: 151,357,591-151,380,047
Locus : 2q23.3
Alt. Genes : RAD50
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