The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TIA1-20-RE | 20 (40 μL) | 200 μL |  |
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| TIA1-20-OR | 20 (40 μL) | 200 μL |  |
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| TIA1-20-GO | 20 (40 μL) | 200 μL |  |
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| TIA1-20-GR | 20 (40 μL) | 200 μL |  |
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| TIA1-20-AQ | 20 (40 μL) | 200 μL |  |
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The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Gene Symbol : TIA1
Gene Name : TIA1 cytotoxic granule associated RNA binding protein
Chromosome : CHR 2: 702,487,92-702,094,43
Locus : 2p13.3
Alt. Genes : SUGP2
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