This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TFAP2B-20-RE | 20 (40 μL) | 200 μL |  |
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| TFAP2B-20-OR | 20 (40 μL) | 200 μL |  |
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| TFAP2B-20-GO | 20 (40 μL) | 200 μL |  |
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| TFAP2B-20-GR | 20 (40 μL) | 200 μL |  |
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| TFAP2B-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
Gene Symbol : TFAP2B
Gene Name : Transcription factor AP-2 beta
Chromosome : CHR 6: 508,176,91-508,476,18
Locus : 6p12.3
Alt. Genes : OPTN
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