This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TCIRG1-20-RE | 20 (40 μL) | 200 μL |  |
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| TCIRG1-20-OR | 20 (40 μL) | 200 μL |  |
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| TCIRG1-20-GO | 20 (40 μL) | 200 μL |  |
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| TCIRG1-20-GR | 20 (40 μL) | 200 μL |  |
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| TCIRG1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
Gene Symbol : TCIRG1
Gene Name : T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Chromosome : CHR 11: 680,389,94-680,538,38
Locus : 11q13.2
Alt. Genes : RBM12
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