The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TAB3-20-RE | 20 (40 μL) | 200 μL |  |
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| TAB3-20-OR | 20 (40 μL) | 200 μL |  |
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| TAB3-20-GO | 20 (40 μL) | 200 μL |  |
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| TAB3-20-GR | 20 (40 μL) | 200 μL |  |
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| TAB3-20-AQ | 20 (40 μL) | 200 μL |  |
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The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : TAB3
Gene Name : TGF-beta activated kinase 1 and MAP3K7 binding protein 3
Chromosome : CHR X: 308,893,93-308,274,41
Locus : Xp21.2
Alt. Genes : PREB
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