This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SUMO4-20-RE | 20 (40 μL) | 200 μL |  |
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| SUMO4-20-OR | 20 (40 μL) | 200 μL |  |
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| SUMO4-20-GO | 20 (40 μL) | 200 μL |  |
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| SUMO4-20-GR | 20 (40 μL) | 200 μL |  |
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| SUMO4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
Gene Symbol : SUMO4
Gene Name : Small ubiquitin-like modifier 4
Chromosome : CHR 6: 149,400,358-149,401,045
Locus : 6q25.1
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