The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SSRP1-20-RE | 20 (40 μL) | 200 μL |  |
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| SSRP1-20-OR | 20 (40 μL) | 200 μL |  |
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| SSRP1-20-GO | 20 (40 μL) | 200 μL |  |
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| SSRP1-20-GR | 20 (40 μL) | 200 μL |  |
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| SSRP1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Symbol : SSRP1
Gene Name : Structure specific recognition protein 1
Chromosome : CHR 11: 573,358,76-573,259,84
Locus : 11q12.1
Alt. Genes : ZNF263
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