The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SKIL-20-RE | 20 (40 μL) | 200 μL |  |
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| SKIL-20-OR | 20 (40 μL) | 200 μL |  |
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| SKIL-20-GO | 20 (40 μL) | 200 μL |  |
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| SKIL-20-GR | 20 (40 μL) | 200 μL |  |
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| SKIL-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Symbol : SKIL
Gene Name : SKI like proto-oncogene
Chromosome : CHR 3: 170,357,677-170,396,848
Locus : 3q26.2
Alt. Genes : LRPPRC
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