This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SIGLEC5-20-RE | 20 (40 μL) | 200 μL |  |
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| SIGLEC5-20-OR | 20 (40 μL) | 200 μL |  |
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| SIGLEC5-20-GO | 20 (40 μL) | 200 μL |  |
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| SIGLEC5-20-GR | 20 (40 μL) | 200 μL |  |
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| SIGLEC5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Gene Symbol : SIGLEC5
Gene Name : Sialic acid binding Ig like lectin 5
Chromosome : CHR 19: 516,304,73-516,109,66
Locus : 19q13.41
Alt. Genes : PRDX4
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