The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SCYL2-20-RE | 20 (40 μL) | 200 μL |  |
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| SCYL2-20-OR | 20 (40 μL) | 200 μL |  |
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| SCYL2-20-GO | 20 (40 μL) | 200 μL |  |
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| SCYL2-20-GR | 20 (40 μL) | 200 μL |  |
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| SCYL2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Symbol : SCYL2
Gene Name : SCY1 like pseudokinase 2
Chromosome : CHR 12: 100,267,136-100,341,723
Locus : 12q23.1
Alt. Genes : ENAM
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