This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RUNX3-20-RE | 20 (40 μL) | 200 μL |  |
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| RUNX3-20-OR | 20 (40 μL) | 200 μL |  |
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| RUNX3-20-GO | 20 (40 μL) | 200 μL |  |
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| RUNX3-20-GR | 20 (40 μL) | 200 μL |  |
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| RUNX3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Symbol : RUNX3
Gene Name : Runt related transcription factor 3
Chromosome : CHR 1: 249,651,57-248,995,10
Locus : 1p36.11
Alt. Genes : OPTN
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