ROCK1 FISH Probe

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ROCK1-20-RE 20 (40 μL) 200 μL color Request Pricing
ROCK1-20-OR 20 (40 μL) 200 μL color Request Pricing
ROCK1-20-GO 20 (40 μL) 200 μL color Request Pricing
ROCK1-20-GR 20 (40 μL) 200 μL color Request Pricing
ROCK1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

Gene Details

Gene Symbol : ROCK1

Gene Name : Rho associated coiled-coil containing protein kinase 1

Chromosome : CHR 18: 211,118,50-209,497,39

Locus : 18q11.1

Request Pricing

Lorem Ipsum is simply dummy text of the printing and typesetting industry.

Lorem Ipsum is simply dummy text of the printing and typesetting industry.