The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF14-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF14-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF14-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF14-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF14-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Gene Symbol : RNF14
Gene Name : Ring finger protein 14
Chromosome : CHR 5: 141,949,336-141,993,708
Locus : 5q31.3
Alt. Genes : SGK2
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