The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF139-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF139-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF139-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF139-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF139-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Gene Symbol : RNF139
Gene Name : Ring finger protein 139
Chromosome : CHR 8: 124,474,766-124,488,617
Locus : 8q24.13
Alt. Genes : KIF20A
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