This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNASE1-20-RE | 20 (40 μL) | 200 μL |  |
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| RNASE1-20-OR | 20 (40 μL) | 200 μL |  |
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| RNASE1-20-GO | 20 (40 μL) | 200 μL |  |
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| RNASE1-20-GR | 20 (40 μL) | 200 μL |  |
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| RNASE1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Symbol : RNASE1
Gene Name : Ribonuclease A family member 1, pancreatic
Chromosome : CHR 14: 208,028,76-208,013,55
Locus : 14q11.2
Alt. Genes : ZNF443
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