This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RFC5-20-RE | 20 (40 μL) | 200 μL |  |
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| RFC5-20-OR | 20 (40 μL) | 200 μL |  |
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| RFC5-20-GO | 20 (40 μL) | 200 μL |  |
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| RFC5-20-GR | 20 (40 μL) | 200 μL |  |
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| RFC5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Symbol : RFC5
Gene Name : Replication factor C subunit 5
Chromosome : CHR 12: 118,016,700-118,033,567
Locus : 12q24.23
Alt. Genes : SGK2
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