This element represents a conserved regulatory region upstream of the rhodopsin (RHO) gene, where the orthologous bovine sequence functions as a RHO enhancer in retinal cells of transgenic mice. This conserved region also shares a region of homology with the opsin locus control region (OPSIN-LCR), which controls cone cell-specific expression of the red/green cone pigment genes on chromosome X. However, the bovine rhodopsin enhancer does not display transgene copy number-dependent or position-independent activity, and it is therefore not an LCR. This human conserved region is thought to bind retina-specific transcription factors, and it forms looping interactions with the RHO gene in rod cells. [provided by RefSeq, May 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RER-20-RE | 20 (40 μL) | 200 μL |  |
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| RER-20-OR | 20 (40 μL) | 200 μL |  |
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| RER-20-GO | 20 (40 μL) | 200 μL |  |
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| RER-20-GR | 20 (40 μL) | 200 μL |  |
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| RER-20-AQ | 20 (40 μL) | 200 μL |  |
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This element represents a conserved regulatory region upstream of the rhodopsin (RHO) gene, where the orthologous bovine sequence functions as a RHO enhancer in retinal cells of transgenic mice. This conserved region also shares a region of homology with the opsin locus control region (OPSIN-LCR), which controls cone cell-specific expression of the red/green cone pigment genes on chromosome X. However, the bovine rhodopsin enhancer does not display transgene copy number-dependent or position-independent activity, and it is therefore not an LCR. This human conserved region is thought to bind retina-specific transcription factors, and it forms looping interactions with the RHO gene in rod cells. [provided by RefSeq, May 2016]
Gene Symbol : RER
Gene Name : Rhodopsin enhancer region
Chromosome : CHR 3: 0-0
Locus : 3q22.1
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