The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RBBP8-20-RE | 20 (40 μL) | 200 μL |  |
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| RBBP8-20-OR | 20 (40 μL) | 200 μL |  |
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| RBBP8-20-GO | 20 (40 μL) | 200 μL |  |
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| RBBP8-20-GR | 20 (40 μL) | 200 μL |  |
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| RBBP8-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : RBBP8
Gene Name : RB binding protein 8, endonuclease
Chromosome : CHR 18: 229,141,20-230,264,85
Locus : 18q11.2
Alt. Genes : ZNF263
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