The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAD18-20-RE | 20 (40 μL) | 200 μL |  |
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| RAD18-20-OR | 20 (40 μL) | 200 μL |  |
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| RAD18-20-GO | 20 (40 μL) | 200 μL |  |
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| RAD18-20-GR | 20 (40 μL) | 200 μL |  |
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| RAD18-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Symbol : RAD18
Gene Name : RAD18, E3 ubiquitin protein ligase
Chromosome : CHR 3: 896,924,8-887,719,5
Locus : 3p25.3
Alt. Genes : LRPPRC
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