This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPN22-20-RE | 20 (40 μL) | 200 μL |  |
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| PTPN22-20-OR | 20 (40 μL) | 200 μL |  |
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| PTPN22-20-GO | 20 (40 μL) | 200 μL |  |
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| PTPN22-20-GR | 20 (40 μL) | 200 μL |  |
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| PTPN22-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Gene Symbol : PTPN22
Gene Name : Protein tyrosine phosphatase, non-receptor type 22
Chromosome : CHR 1: 113,871,760-113,813,810
Locus : 1p13.2
Alt. Genes : ZNF263
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