This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKD3-20-RE | 20 (40 μL) | 200 μL |  |
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| PRKD3-20-OR | 20 (40 μL) | 200 μL |  |
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| PRKD3-20-GO | 20 (40 μL) | 200 μL |  |
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| PRKD3-20-GR | 20 (40 μL) | 200 μL |  |
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| PRKD3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Gene Symbol : PRKD3
Gene Name : Protein kinase D3
Chromosome : CHR 2: 373,248,02-372,505,01
Locus : 2p22.2
Alt. Genes : DNAL4
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