This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRDM2-20-RE | 20 (40 μL) | 200 μL |  |
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| PRDM2-20-OR | 20 (40 μL) | 200 μL |  |
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| PRDM2-20-GO | 20 (40 μL) | 200 μL |  |
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| PRDM2-20-GR | 20 (40 μL) | 200 μL |  |
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| PRDM2-20-AQ | 20 (40 μL) | 200 μL |  |
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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Symbol : PRDM2
Gene Name : PR/SET domain 2
Chromosome : CHR 1: 136,988,74-138,250,78
Locus : 1p36.21
Alt. Genes : CELA3A
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