This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPOX-20-RE | 20 (40 μL) | 200 μL |  |
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| PPOX-20-OR | 20 (40 μL) | 200 μL |  |
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| PPOX-20-GO | 20 (40 μL) | 200 μL |  |
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| PPOX-20-GR | 20 (40 μL) | 200 μL |  |
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| PPOX-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Symbol : PPOX
Gene Name : Protoporphyrinogen oxidase
Chromosome : CHR 1: 161,165,727-161,178,276
Locus : 1q23.3
Alt. Genes : ARL4C
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