This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLA2G1B-20-RE | 20 (40 μL) | 200 μL |  |
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| PLA2G1B-20-OR | 20 (40 μL) | 200 μL |  |
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| PLA2G1B-20-GO | 20 (40 μL) | 200 μL |  |
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| PLA2G1B-20-GR | 20 (40 μL) | 200 μL |  |
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| PLA2G1B-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Symbol : PLA2G1B
Gene Name : Phospholipase A2 group IB
Chromosome : CHR 12: 120,327,788-120,322,110
Locus : 12q24.31
Alt. Genes : OPTN
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