The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PIM1-20-RE | 20 (40 μL) | 200 μL |  |
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| PIM1-20-OR | 20 (40 μL) | 200 μL |  |
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| PIM1-20-GO | 20 (40 μL) | 200 μL |  |
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| PIM1-20-GR | 20 (40 μL) | 200 μL |  |
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| PIM1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Gene Symbol : PIM1
Gene Name : Pim-1 proto-oncogene, serine/threonine kinase
Chromosome : CHR 6: 371,701,45-371,754,27
Locus : 6p21.2
Alt. Genes : RBM12
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