The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDLIM3-20-RE | 20 (40 μL) | 200 μL |  |
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| PDLIM3-20-OR | 20 (40 μL) | 200 μL |  |
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| PDLIM3-20-GO | 20 (40 μL) | 200 μL |  |
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| PDLIM3-20-GR | 20 (40 μL) | 200 μL |  |
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| PDLIM3-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Gene Symbol : PDLIM3
Gene Name : PDZ and LIM domain 3
Chromosome : CHR 4: 185,535,605-185,500,659
Locus : 4q35.1
Alt. Genes : LRPPRC
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