This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDGFRA-20-RE | 20 (40 μL) | 200 μL |  |
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| PDGFRA-20-OR | 20 (40 μL) | 200 μL |  |
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| PDGFRA-20-GO | 20 (40 μL) | 200 μL |  |
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| PDGFRA-20-GR | 20 (40 μL) | 200 μL |  |
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| PDGFRA-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Gene Symbol : PDGFRA
Gene Name : Platelet derived growth factor receptor alpha
Chromosome : CHR 4: 542,290,96-542,982,44
Locus : 4q12
Alt. Genes : SGK2
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