This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PARP1-20-RE | 20 (40 μL) | 200 μL |  |
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| PARP1-20-OR | 20 (40 μL) | 200 μL |  |
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| PARP1-20-GO | 20 (40 μL) | 200 μL |  |
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| PARP1-20-GR | 20 (40 μL) | 200 μL |  |
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| PARP1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Gene Symbol : PARP1
Gene Name : Poly(ADP-ribose) polymerase 1
Chromosome : CHR 1: 226,408,099-226,360,690
Locus : 1q42.12
Alt. Genes : MKRN3-AS1
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