This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PARL-20-RE | 20 (40 μL) | 200 μL |  |
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| PARL-20-OR | 20 (40 μL) | 200 μL |  |
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| PARL-20-GO | 20 (40 μL) | 200 μL |  |
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| PARL-20-GR | 20 (40 μL) | 200 μL |  |
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| PARL-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
Gene Symbol : PARL
Gene Name : Presenilin associated rhomboid like
Chromosome : CHR 3: 183,884,907-183,826,487
Locus : 3q27.1
Alt. Genes : FRY
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