This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OTULIN-20-RE | 20 (40 μL) | 200 μL |  |
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| OTULIN-20-OR | 20 (40 μL) | 200 μL |  |
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| OTULIN-20-GO | 20 (40 μL) | 200 μL |  |
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| OTULIN-20-GR | 20 (40 μL) | 200 μL |  |
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| OTULIN-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]
Gene Symbol : OTULIN
Gene Name : OTU deubiquitinase with linear linkage specificity
Chromosome : CHR 5: 146,607,93-147,165,51
Locus : 5p15.2
Alt. Genes : KIF20A
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