This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NSMCE2-20-RE | 20 (40 μL) | 200 μL |  |
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| NSMCE2-20-OR | 20 (40 μL) | 200 μL |  |
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| NSMCE2-20-GO | 20 (40 μL) | 200 μL |  |
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| NSMCE2-20-GR | 20 (40 μL) | 200 μL |  |
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| NSMCE2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Symbol : NSMCE2
Gene Name : NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Chromosome : CHR 8: 125,091,817-125,367,124
Locus : 8q24.13
Alt. Genes : FEM1B
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