This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NR1I2-20-RE | 20 (40 μL) | 200 μL |  |
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| NR1I2-20-OR | 20 (40 μL) | 200 μL |  |
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| NR1I2-20-GO | 20 (40 μL) | 200 μL |  |
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| NR1I2-20-GR | 20 (40 μL) | 200 μL |  |
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| NR1I2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : NR1I2
Gene Name : Nuclear receptor subfamily 1 group I member 2
Chromosome : CHR 3: 119,780,483-119,818,484
Locus : 3q13.33
Alt. Genes : RBM12
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