This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NLRP1-20-RE | 20 (40 μL) | 200 μL |  |
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| NLRP1-20-OR | 20 (40 μL) | 200 μL |  |
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| NLRP1-20-GO | 20 (40 μL) | 200 μL |  |
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| NLRP1-20-GR | 20 (40 μL) | 200 μL |  |
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| NLRP1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : NLRP1
Gene Name : NLR family pyrin domain containing 1
Chromosome : CHR 17: 558,451,1-550,139,8
Locus : 17p13.2
Alt. Genes : KCNMB2
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