This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFKBIZ-20-RE | 20 (40 μL) | 200 μL |  |
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| NFKBIZ-20-OR | 20 (40 μL) | 200 μL |  |
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| NFKBIZ-20-GO | 20 (40 μL) | 200 μL |  |
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| NFKBIZ-20-GR | 20 (40 μL) | 200 μL |  |
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| NFKBIZ-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : NFKBIZ
Gene Name : NFKB inhibitor zeta
Chromosome : CHR 3: 101,827,989-101,861,024
Locus : 3q12.3
Alt. Genes : ZNF263
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