NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NELFB-20-RE | 20 (40 μL) | 200 μL |  |
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| NELFB-20-OR | 20 (40 μL) | 200 μL |  |
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| NELFB-20-GO | 20 (40 μL) | 200 μL |  |
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| NELFB-20-GR | 20 (40 μL) | 200 μL |  |
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| NELFB-20-AQ | 20 (40 μL) | 200 μL |  |
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NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
Gene Symbol : NELFB
Gene Name : Negative elongation factor complex member B
Chromosome : CHR 9: 137,255,299-137,273,547
Locus : 9q34.3
Alt. Genes : OPTN
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