The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MARC2-20-RE | 20 (40 μL) | 200 μL |  |
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| MARC2-20-OR | 20 (40 μL) | 200 μL |  |
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| MARC2-20-GO | 20 (40 μL) | 200 μL |  |
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| MARC2-20-GR | 20 (40 μL) | 200 μL |  |
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| MARC2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]
Gene Symbol : MARC2
Gene Name : Mitochondrial amidoxime reducing component 2
Chromosome : CHR 1: 220,748,245-220,784,814
Locus : 1q41
Alt. Genes : MPHOSPH10
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