The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAPRE1-20-RE | 20 (40 μL) | 200 μL |  |
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| MAPRE1-20-OR | 20 (40 μL) | 200 μL |  |
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| MAPRE1-20-GO | 20 (40 μL) | 200 μL |  |
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| MAPRE1-20-GR | 20 (40 μL) | 200 μL |  |
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| MAPRE1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Gene Symbol : MAPRE1
Gene Name : Microtubule associated protein RP/EB family member 1
Chromosome : CHR 20: 328,197,79-328,504,04
Locus : 20q11.21
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