This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MALRD1-20-RE | 20 (40 μL) | 200 μL |  |
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| MALRD1-20-OR | 20 (40 μL) | 200 μL |  |
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| MALRD1-20-GO | 20 (40 μL) | 200 μL |  |
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| MALRD1-20-GR | 20 (40 μL) | 200 μL |  |
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| MALRD1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]
Gene Symbol : MALRD1
Gene Name : MAM and LDL receptor class A domain containing 1
Chromosome : CHR 10: 190,469,30-197,344,77
Locus : 10p12.31
Alt. Genes : ENAM
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