This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LIG1-20-RE | 20 (40 μL) | 200 μL |  |
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| LIG1-20-OR | 20 (40 μL) | 200 μL |  |
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| LIG1-20-GO | 20 (40 μL) | 200 μL |  |
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| LIG1-20-GR | 20 (40 μL) | 200 μL |  |
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| LIG1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Symbol : LIG1
Gene Name : DNA ligase 1
Chromosome : CHR 19: 481,706,02-481,154,44
Locus : 19q13.33
Alt. Genes : OPTN
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