After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INS-20-RE | 20 (40 μL) | 200 μL |  |
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| INS-20-OR | 20 (40 μL) | 200 μL |  |
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| INS-20-GO | 20 (40 μL) | 200 μL |  |
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| INS-20-GR | 20 (40 μL) | 200 μL |  |
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| INS-20-AQ | 20 (40 μL) | 200 μL |  |
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After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Symbol : INS
Gene Name : Insulin
Chromosome : CHR 11: 216,120,8-215,977,8
Locus : 11p15.5
Alt. Genes : AKAP9
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