The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ING3-20-RE | 20 (40 μL) | 200 μL |  |
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| ING3-20-OR | 20 (40 μL) | 200 μL |  |
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| ING3-20-GO | 20 (40 μL) | 200 μL |  |
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| ING3-20-GR | 20 (40 μL) | 200 μL |  |
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| ING3-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Symbol : ING3
Gene Name : Inhibitor of growth family member 3
Chromosome : CHR 7: 120,950,754-120,975,656
Locus : 7q31.31
Alt. Genes : PREB
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