The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL18BP-20-RE | 20 (40 μL) | 200 μL |  |
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| IL18BP-20-OR | 20 (40 μL) | 200 μL |  |
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| IL18BP-20-GO | 20 (40 μL) | 200 μL |  |
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| IL18BP-20-GR | 20 (40 μL) | 200 μL |  |
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| IL18BP-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Symbol : IL18BP
Gene Name : Interleukin 18 binding protein
Chromosome : CHR 11: 719,979,43-720,029,18
Locus : 11q13.4
Alt. Genes : WASF2
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