The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL12RB1-20-RE | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-OR | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-GO | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-GR | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Symbol : IL12RB1
Gene Name : Interleukin 12 receptor subunit beta 1
Chromosome : CHR 19: 180,990,26-180,589,93
Locus : 19p13.11
Alt. Genes : WASF2
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