This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IGF1R-20-RE | 20 (40 μL) | 200 μL |  |
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| IGF1R-20-OR | 20 (40 μL) | 200 μL |  |
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| IGF1R-20-GO | 20 (40 μL) | 200 μL |  |
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| IGF1R-20-GR | 20 (40 μL) | 200 μL |  |
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| IGF1R-20-AQ | 20 (40 μL) | 200 μL |  |
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This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Symbol : IGF1R
Gene Name : Insulin like growth factor 1 receptor
Chromosome : CHR 15: 986,485,38-989,645,29
Locus : 15q26.3
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